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Design and fabrication of magnetically functionalised core/shell microspheres for smart drug delivery
Faculty of Engineering - Papers (Archive)
  • Xiuqing Gong, Hong Kong University of Science and Technology
  • Suili Peng, Hong Kong University of Science and Technology
  • Weijia Wen, Hong Kong University of Science and Technology,The Hong Kong University Of Science And Technology
  • Ping Sheng, Hong Kong University of Science and Technology
  • Weihua Li, University of Wollongong
RIS ID
25649
Publication Date
1-1-2009
Publication Details

Gong, X., Peng, S., Wen, W., Sheng, P. & Li, W. (2009). Design and fabrication of magnetically functionalised core/shell microspheres for smart drug delivery. Advanced Functional Materials, 19 (2), 292-297.

Abstract

The fabrication of magnetically functionalized core/shell microspheres by using the microfluidic flow-focusing (MFF) approach is reported. The shell of each microsphere is embedded with magnetic nanoparticles, thereby enabling the microspheres to deform under an applied magnetic field. By encapsulating a drug, for example, aspirin, inside the microspheres, the drug release of the microspheres is enhanced under the compression–extension oscillations that are induced by an AC magnetic field. This active pumping mode of drug release can be controlled by varying the frequency and magnitude of the applied magnetic field as well as the time profile of the magnetic field. UV absorption measurements of cumulative aspirin release are carried out to determine the influence of these factors. The drug release behavior is found to be significantly different depending on whether the applied field varies sinusoidally or in a step-function manner with time.

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Citation Information
Xiuqing Gong, Suili Peng, Weijia Wen, Ping Sheng, et al.. "Design and fabrication of magnetically functionalised core/shell microspheres for smart drug delivery" (2009) p. 292 - 297
Available at: http://works.bepress.com/weihua_li/175/