After a brief background about the epidemiology of Hepatitis B, C and HIV, strategies for their prevention are discussed in the paediatric population of developing countries. These strategies are focused on mother to child transmission, misuse of injections, use of infected needles, myths and use of material infected with the hepatitis positive patient such as a comb, tooth brush etc. Malnutrition and its relationship with Tuberculosis and HIV infection are discussed. World Health Organization (WHO) guidelines on the management of malnutrition, Tuberculosis and HIV are discussed briefly. A real scenario highlighting the existence of HBV, HCV and HIV is described. Finally role of policy makers, NGO, WHO and local governments in the prevention of HBV, HCV and HIV in the paediatric population is discussed.