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Selected Works of Walter J. Urba, MD, PhD
Article
The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation.
Nanoscale Res Lett
  • Yongbin Mou, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Yun Xing, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Hongyan Ren, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Zhihua Cui, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Yu Zhang
  • Guangjie Yu, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Walter J Urba, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
  • Qingang Hu
  • Hongming Hu, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA.
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Document Type
Article
Publication Date
12-1-2017
Keywords
  • Adjuvant,
  • Antigen cross-presentation,
  • Dendritic cells,
  • Superparamagnetic iron oxide
Disciplines
Abstract

Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical modifications and surface charges were used to study the mechanism of action of antigen delivery. Specifically, two types of magnetic NPs, γFe

Clinical Institute
Cancer
Specialty
Oncology
Specialty
Earle A. Chiles Research Institute
Citation Information
Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, et al.. "The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation." Nanoscale Res Lett (2017)
Available at: http://works.bepress.com/walter-urba/302/