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Selected Works of Walter J. Urba, MD, PhD
Other
Short-term anti-CD3 stimulation of lymphocytes to increase their in vivo acitivity
(1992)
  • Augusto C. Ochoa, University of Minnesota
  • Cynthia Loeffler, University of Minnesota
  • Walter Urba, University of Minnesota
  • Dan L. Longo, University of Minnesota
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Abstract
The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
Disciplines
Publication Date
July 10, 1992
Comments
United States Patent 5316763
Citation Information
Augusto C. Ochoa, Cynthia Loeffler, Walter Urba and Dan L. Longo. "Short-term anti-CD3 stimulation of lymphocytes to increase their in vivo acitivity" (1992)
Available at: http://works.bepress.com/walter-urba/248/