Skip to main content
Presentation
Use of P-Values to Evaluate the Probability of a Genuine Finding in Large-Scale Genetic Association Studies
American Society of Human Genetics Annual Meeting (2013)
  • Olga A. Vsevolozhskaya, Michigan State University
  • Qing Lu, Michigan State University
  • Chia-Ling Kuo
  • Dmitri V. Zaykin
Abstract

To claim the existence of an association in modern genome-wide association studies (GWAS), a nominal P-value has to exceed a stringent Bonferroni-adjusted significance level. Despite strictness of the correction, a significant P-value does not indicate high probability that the claimed association is genuine. A simple Bayesian solution -- the False Positive Report Probability (FPRP) -- was previously proposed to convert the observed P-value to the corresponding probability of no true association. Although the FPRP solution is highly popular, it does not reflect probability that a particular finding is false. Here, we offer a simple POFIG method -- a Probability that a Finding is Genuine. POFIG enables one effectively to convert a P-value to the probability that a particular association with the trait is genuine. The validity of POFIG is supported by the results of a simulation study and the potential utility of our approach is discussed with reference to future GWAS discoveries.

Keywords
  • P-values,
  • probability,
  • genetic association studies
Disciplines
Publication Date
October, 2013
Citation Information
Olga A. Vsevolozhskaya, Qing Lu, Chia-Ling Kuo and Dmitri V. Zaykin. "Use of P-Values to Evaluate the Probability of a Genuine Finding in Large-Scale Genetic Association Studies" American Society of Human Genetics Annual Meeting (2013)
Available at: http://works.bepress.com/vsevolozhskaya/14/