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Selected Works of Dr. Vivian McAlister O.C.
Article
Early Steroid Withdrawal after Liver Transplantation: The Canadian Tacrolimus versus Microemulsion Cyclosporin A Trial: 1-year Follow-up
Liver Transplantation (2003)
  • Paul Greig, University of Toronto
  • Leslie Lilly, University of Toronto
  • Charles Scudamore, University of British Columbia
  • Siegfried Erb, University of British Columbia
  • Eric Yoshida, University of British Columbia
  • Norman Kneteman, University of Alberta
  • Vince Bain, University of Alberta
  • Cameron Ghent, The University of Western Ontario
  • Paul Marotta, The University of Western Ontario
  • David Grant, The University of Western Ontario
  • William Wall, The University of Western Ontario
  • Jean Tchervenkov, McGill University
  • Jeffrey Barkun, McGill University
  • Andre Roy, University of Montreal
  • Denis Marleau, University of Montreal
  • Vivian McAlister, Dalhousie University
  • Kevork Peltekian, Dalhousie University
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Abstract

Corticosteroid therapy contributes significant toxicity to liver transplantation. The safety and efficacy of early steroid withdrawal were determined in patients treated with either tacrolimus or microemulsion cyclosporin A (micro-CsA). The primary outcome was the proportion of patients who were steroid-free 1 year posttransplantation. From the seven Canadian adult liver transplant centers, 143 patients were randomly allocated oral treatment with either tacrolimus (n = 71) or micro-CsA (n = 72), together with corticosteroids and azathioprine. Eligibility criteria for steroid withdrawal included freedom from acute rejection for a minimum of 3 months, and prednisone

Keywords
  • Adrenal Cortex Hormones,
  • Canada,
  • Cyclosporine,
  • Emulsions,
  • Graft Rejection,
  • Graft Survival,
  • Immunosuppressive Agents,
  • Liver Transplantation,
  • Tacrolimus
Disciplines
Publication Date
June, 2003
Publisher Statement
Dr. Vivian McAlister is currently a faculty member at The University of Western Ontario.
Citation Information
Paul Greig, Leslie Lilly, Charles Scudamore, Siegfried Erb, et al.. "Early Steroid Withdrawal after Liver Transplantation: The Canadian Tacrolimus versus Microemulsion Cyclosporin A Trial: 1-year Follow-up" Liver Transplantation Vol. 9 Iss. 6 (2003)
Available at: http://works.bepress.com/vivianmcalister/79/