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Reuse of liver grafts following brain death of the initial recipient
World Journal of Hepatology (2014)
  • Hideaki Tanaka
  • Vivian C. McAlister
  • Mark Levstik, University of Western Ontario
  • Cameron Ghent, University of Western Ontario
  • Paul Marotta, University of Western Ontario
  • Douglas Quan, University of Western Ontario
  • William Wall, University of Western Ontario

AIM: To determine if there is a reasonable prospect of success of a re-use liver transplantation.

METHODS: We systematically searched for reports of liver graft re-use using electronic searches of PubMed and Web of Knowledge. We performed hand searches of references lists of articles reporting re-use of grafts.

RESULTS:A systematic review of the literature reveals 28 liver transplantations using previously transplanted grafts. First and second recipients ranged in age from 4 to 72 years and 29 to 62 years respectively. Liver disease in the first recipient was varied including 5 (18%) patients with fulminant liver failure who died subsequently of cerebral edema. The second transplantation was performed after a median interval of 5 d (one day-13 years). Viral hepatitis was present in 3 (11%) of the initial recipients and in 8 (29%) of final recipients. hepatocellular carcinoma was present in 6 (21%) of the final recipients. Early survival after the final transplantation was 93%, whereas long-term survival was 78% with a mean follow-up of 23.3 (3-120) mo.

CONCLUSION: Outcomes of transplantation using previously transplanted grafts in this select population are similar to those seen with conventional grafts.

  • Reuse; Liver graft; Brain death; Liver transplantation
Publication Date
June, 2014
Citation Information
Tanaka H, McAlister VC, Levstik M, Ghent C, Marotta P, Quan D, Wall W. Reuse of liver grafts following brain death of the initial recipient. World J Hepatol 2014; 6.6: 443-447. Full text available in PubMed Central