Article
Nanoparticles featuring amino acid-functionalized side chains as DNA receptors
Chemical Biology & Drug Design
(2007)
Abstract
A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.
Keywords
- amino acid,
- DNA,
- nanoparticle
Disciplines
Publication Date
June 25, 2007
Publisher Statement
doi: 10.1111/j.1747-0285.2007.00534.x
Citation Information
PS Ghosh, G Han, B Erdogan, O Rosado, et al.. "Nanoparticles featuring amino acid-functionalized side chains as DNA receptors" Chemical Biology & Drug Design Vol. 70 Iss. 1 (2007) Available at: http://works.bepress.com/vincent_rotello/49/