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Core-like particles of an enveloped animal virus can self-assemble efficiently on artificial templates
Nano Letters (2007)
  • NL Goicochea
  • M De
  • VM Rotello
  • S Mukhopadhyay
  • B Dragnea
Abstract

Alphaviruses are animal viruses holding great promise for biomedical applications as drug delivery vectors, functional imaging probes, and nanoparticle delivery vesicles because of their efficient in vitro self-assembly properties. However, due to their complex structure, with a protein capsid encapsulating the genome and an outer membrane composed of lipids and glycoproteins, the in-vitro self-assembly of virus-like particles, which have the functional virus coat but carry an artificial cargo, can be challenging. Fabrication of such alphavirus-like particles is likely to require a two-step process: first, the assembly of a capsid structure around an artificial core, second the addition of the membrane layer. Here we report progress made on the first step: the efficient self-assembly of the alphavirus capsid around a functionalized nanoparticle core.

Disciplines
Publication Date
January 24, 2007
Publisher Statement
DOI: 10.1021/nl070860e Copyright © 2007 American Chemical Society
Citation Information
NL Goicochea, M De, VM Rotello, S Mukhopadhyay, et al.. "Core-like particles of an enveloped animal virus can self-assemble efficiently on artificial templates" Nano Letters Vol. 7 Iss. 8 (2007)
Available at: http://works.bepress.com/vincent_rotello/36/