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The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events
Genes & Development (1987)
  • Victor R. Ambros, Massachusetts Institute of Technology
  • H. Robert Horvitz, Massachusetts Institute of Technology
Abstract
The lin-14 locus of Caenorhabditis elegans plays an important role in specifying the normal timing and sequence of developmental events in the lateral hypodermal cell lineages. The results of gene dosage, complementation, and temperature-shift experiments indicate that the fates expressed by cells at successive stages of these cell lineages are specified by the level of lin-14 activity and that lin-14 acts at multiple times during development to control stage-specific choices of cell fate. Our observations suggest that during normal development a reduction in the level of lin-14 gene function causes the sequential expression of stage-specific cell fates.
Publication Date
June, 1987
Publisher Statement

Citation: Ambros V, Horvitz HR. The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes Dev. 1987 Jun;1(4):398-414. PubMed PMID: 3678829.

Publisher PDF posted as allowed by the publisher's author rights policy at http://genesdev.cshlp.org/site/misc/terms.xhtml.

Citation Information
Victor R. Ambros and H. Robert Horvitz. "The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events" Genes & Development Vol. 1 Iss. 4 (1987)
Available at: http://works.bepress.com/victor_ambros/84/