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Article
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
Cell (1989)
  • Victor R. Ambros, Harvard University
Abstract
The heterochronic genes lin-4, lin-14, lin-28, and lin-29 control the timing of specific postembryonic developmental events in C. elegans. The experiments described here examine how these four genes interact to control a particular stage-specific event of the lateral hypodermal cell lineages. This event, termed the "larva-to-adult switch" (L/A switch), involves several coordinate changes in the behavior of hypodermal cells at the fourth molt: cessation of cell division, formation of adult (instead of larval) cuticle, cell fusion, and cessation of the molting cycle. The phenotypes of multiply mutant strains suggest a model wherein the L/A switch is controlled by the stage-specific activity of a regulatory hierarchy: At early stages of wild-type development, lin-14 and lin-28 inhibit lin-29 and thus prevent switching. Later, lin-4 inhibits lin-14 and lin-28, allowing activation of lin-29, which in turn triggers the switch in the L4 stage. lin-29 may activate the L/A switch by regulating genes that control cell division, differentiation, and stage-specific gene expression in hypodermal cells.
Publication Date
April 7, 1989
Publisher Statement
Citation: Ambros V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell. 1989 Apr 7;57(1):49-57. PubMed PMID:2702689.
Citation Information
Victor R. Ambros. "A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans" Cell Vol. 57 Iss. 1 (1989)
Available at: http://works.bepress.com/victor_ambros/82/