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Article
Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells
Cell (1996)
  • Susan Euling, Harvard University
  • Victor R. Ambros, Dartmouth College
Abstract
Heterochronic genes control the timing of vulval development in the C. elegans hermaphrodite. lin-14 or lin-28 loss-of-function mutations cause the vulval precursor cells (VPCs) to enter S phase and to divide one larval stage earlier than in the wild type. A precocious vulva is formed by essentially normal cell lineage patterns, governed by the same intercellular signals as in the wild type. Mutations that prevent the normal developmental down-regulation of lin-14, activity delay or block VPC division and prevent vulval differentiation. A genetic pathway that includes lin-4, lin-14, and lin-28 controls when VPCs complete G1 and also controls when VPCs acquire the competence to respond to the intercellular patterning signals and express vulval fates.
Publication Date
March 8, 1996
Publisher Statement
Citation: Euling S, Ambros V. Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells. Cell. 1996 Mar 8;84(5):667-76. PubMed PMID: 8625405.
Citation Information
Susan Euling and Victor R. Ambros. "Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells" Cell Vol. 84 Iss. 5 (1996)
Available at: http://works.bepress.com/victor_ambros/73/