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The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans
Program in Molecular Medicine Publications and Presentations
  • Gabriel D. Bosse, Laval University Cancer Research Centre
  • Stefan Ruegger, University of Basel
  • Maria C. Ow, University of Massachusetts Medical School
  • Alejandro Vasquez-Rifo, Laval University Cancer Research Centre
  • Evelyne L. Rondeau, Laval University Cancer Research Centre
  • Victor R. Ambros, University of Massachusetts Medical School
  • Helge Grosshans, Friedrich Miescher Institute for Biomedical Research
  • Martin J. Simard, Laval University Cancer Research Centre
UMMS Affiliation
Program in Molecular Medicine
Date
4-25-2013
Document Type
Article
Medical Subject Headings
Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Exoribonucleases; Gene Expression; MicroRNAs; Mutation; N-Glycosyl Hydrolases; RNA Interference; RNA Stability; RNA, Helminth; RNA-Induced Silencing Complex
Abstract

In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a multitude of mechanisms influencing their transcription and posttranscriptional maturation. However, there is only sparse knowledge on pathways regulating the mature, functional form of microRNA. Here, we uncover the implication of the decapping scavenger protein DCS-1 in the control of microRNA turnover. In Caenorhabditis elegans, mutations in dcs-1 increase the levels of functional microRNAs. We demonstrate that DCS-1 interacts with the exonuclease XRN-1 to promote microRNA degradation in an independent manner from its known decapping scavenger activity, establishing two molecular functions for DCS-1. Our findings thus indicate that DCS-1 is part of a degradation complex that performs microRNA turnover in animals.

Rights and Permissions
Citation: Mol Cell. 2013 Apr 25;50(2):281-7. doi: 10.1016/j.molcel.2013.02.023. Epub 2013 Mar 28. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
23541767
Citation Information
Gabriel D. Bosse, Stefan Ruegger, Maria C. Ow, Alejandro Vasquez-Rifo, et al.. "The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans" Vol. 50 Iss. 2 (2013) ISSN: 1097-2765 (Linking)
Available at: http://works.bepress.com/victor_ambros/30/