The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegansProgram in Molecular Medicine Publications and Presentations
UMMS AffiliationProgram in Molecular Medicine
Medical Subject HeadingsAnimals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Insulin; Larva; Signal Transduction; Time Factors; Transcription Factors; Transforming Growth Factor beta
AbstractAnimals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.
Related ResourcesLink to Article in PubMed
Citation InformationXantha Karp and Victor R. Ambros. "The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans" Vol. 187 Iss. 1 (2011) ISSN: 0016-6731 (Linking)
Available at: http://works.bepress.com/victor_ambros/25/