MicroRNAs and developmental timingProgram in Molecular Medicine Publications and Presentations
UMMS AffiliationProgram in Molecular Medicine
Medical Subject HeadingsAnimals; Caenorhabditis elegans; Cell Differentiation; Cell Lineage; *Gene Expression Regulation, Developmental; Humans; MicroRNAs
AbstractMicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.
Related ResourcesLink to Article in PubMed
Citation InformationVictor R. Ambros. "MicroRNAs and developmental timing" Vol. 21 Iss. 4 (2011) ISSN: 0959-437X (Linking)
Available at: http://works.bepress.com/victor_ambros/21/