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Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
Program in Molecular Medicine Publications and Presentations
  • Nicholas S. Sokol, Dartmouth College
  • Peizhang Xu, Howard Hughes Medical Institute
  • Yuh-Nung Jan, Howard Hughes Medical Institute
  • Victor R. Ambros, University of Massachusetts Medical School
UMMS Affiliation
Program in Molecular Medicine
Date
6-15-2008
Document Type
Article
Medical Subject Headings
Animals; Animals, Genetically Modified; Drosophila; Female; Gene Expression Regulation, Developmental; Larva; Life Cycle Stages; Male; Metamorphosis, Biological; MicroRNAs; Muscles; Nervous System; Neuromuscular Junction; Transgenes
Abstract

The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition is carried out predominantly by let-7 alone. This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior.

Comments

Citation: Genes Dev. 2008 Jun 15;22(12):1591-6. doi: 10.1101/gad.1671708. Link to article on publisher's site

Publisher PDF posted as allowed by the publisher's author rights policy at http://genesdev.cshlp.org/site/misc/terms.xhtml.

Related Resources
Link to Article in PubMed
Keywords
  • let-7,
  • let-7-Complex,
  • microRNA,
  • heterochronic developmental timing,
  • neuromuscular junction
PubMed ID
18559475
Creative Commons License
Creative Commons Attribution-Noncommercial 4.0
Citation Information
Nicholas S. Sokol, Peizhang Xu, Yuh-Nung Jan and Victor R. Ambros. "Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis" Vol. 22 Iss. 12 (2008) ISSN: 0890-9369 (Linking)
Available at: http://works.bepress.com/victor_ambros/10/