"The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis" by Tyler A. Johnson

Selected Works of Tyler Johnson

Follow Contact

Article

The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis

Journal of Organic Chemistry (2008)

Tyler A. Johnson, University of California, Santa Cruz
Taro Amagata, University of California, Santa Cruz
Allen G Oliver, University of California, Santa Cruz
Karen Tenney, University of California, Santa Cruz
Frederick A Valeriote, Henry Ford Health System
Phillip Crews, University of California, Santa Cruz

Find in your library

Abstract

A reinvestigation of a Fijian collection of Cacospongia mycofijiensis has yielded the known mycothiazole and a novel heterocyclic, CTP-431 (1). Its structure including absolute configuration as 8R,9R,10S,13S was established using NMR data, calculated DFT 13C chemical shifts and results from X-ray crystallography. It is possible that the tricyclic skeleton of CTP-431 (1) is biosynthetically related to the macrolide latrunculin A, however the thiopyrone moiety of 1 has no previous precedent in natural products chemistry.

Disciplines

Life Sciences

Publication Date

2008

DOI

https://doi.or/10.1021/jo801096m

Citation Information

Tyler A. Johnson, Taro Amagata, Allen G Oliver, Karen Tenney, et al.. "The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis" Journal of Organic Chemistry Vol. 73 (2008) p. 7255 - 7259 ISSN: 0022-326
Available at: http://works.bepress.com/tyler-a-johnson/25/