"A reassignment of (-)-mycothiazole and the isolation of a related diol." by Rachel N. Sonnenschein

Selected Works of Tyler Johnson

Follow Contact

Article

A reassignment of (-)-mycothiazole and the isolation of a related diol.

Natural Sciences and Mathematics | Faculty Scholarship

Rachel N. Sonnenschein, University of California, Santa Cruz, California, USA
Tyler A. Johnson, University of California, Santa Cruz, California, USA
Karen Tenney, University of California, Santa Cruz, California, USA
Frederick A. Valeriote, University of California, Santa Cruz, California, USA
Phillip Crews, University of California, Santa Cruz, California, USA

Link Find in your library

Department

Natural Sciences and Mathematics

Document Type

Article

Source

Journal of Natural Products

Publication Date

1-1-2006

Disciplines

Abstract

A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.

PubMed ID

16441088

Comments

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.

Rights

Publisher's Statement

Citation Information

Rachel N. Sonnenschein, Tyler A. Johnson, Karen Tenney, Frederick A. Valeriote, et al.. "A reassignment of (-)-mycothiazole and the isolation of a related diol." Vol. 69 Iss. 1 (2006) p. 145 - 147 ISSN: 0163-3864
Available at: http://works.bepress.com/tyler-a-johnson/21/