Effects of intraovarian infusion of insulin-like growth factor-I on ovarian follicular function in cattleDomestic Animal Endocrinology (2000)
AbstractThe objective of this study was to determine if increased secretion of intraovarian insulin-like growth factor-I (IGF-I), experimentally induced via minipumps, affects follicular function in cattle. Fourteen cycling Holstein cows were divided equally into two groups: Control, osmotic minipumps (containing vehicle) surgically inserted into each ovary, or IGF-I treated, osmotic minipumps as in Controls but pumping 2.0 microg of recombinant human IGF-I per hr for 7 days. All cows were synchronized with prostaglandin F(2alpha) 0.10) between Control and IGF-I-treated cows during Days 2 to 6 of treatment. IGF-I treatment increased (P<0.05) estradiol concentrations in follicular fluid of small follicles, but had no effect (P<0.10) on estradiol concentrations in follicular fluid of large follicles, or on progesterone, androstenedione, or IGF binding protein concentrations in small or large follicles. We conclude that a 7-day infusion of IGF-I directly into the stroma of the ovary altered follicular growth and follicular fluid estradiol concentrations.
Citation InformationL J Spicer, P Alvares, Tulio M Prado, G L Morgan, et al.. "Effects of intraovarian infusion of insulin-like growth factor-I on ovarian follicular function in cattle" Domestic Animal Endocrinology Vol. 18 Iss. 2 (2000)
Available at: http://works.bepress.com/tulio_prado/9/