This study presents a technology assessment for reducing nosocomial infections. Nosocomial infections (also known as hospital-acquired infection or HAI) present numerous problems for healthcare institutions including increased costs, increased use of hazardous cleaners, and patient reluctance toward treatment. The goal is to incorporate more than the traditional economic point of view in evaluating alternatives for reducing infections. The Analytical Hierarchy Process is used to assess the feasibility of candidate technologies. Traditional criteria such as infection reduction and cost are used in addition compatibility with existing procedures, and staff acceptance was used for evaluating technologies. Infection reduction and staff acceptance were determined to be the most important criterion through expert interviews. The analysis established that utilizing RFID for handwashing compliance was the superior technology given its superior reduction in HAIs and good staff and patent acceptance.