Since 1970, much of state and local activity in environmental protection involved implementing or enforcing national mandates. Recent developments in the United States suggest that some subnational jurisdictions have taken and are taking significant steps to address local environmental problems within, and beyond, national mandates. This suggests that there may be opportunities for state and local governments to address emerging local environmental policy issues. With any opportunity to address emerging local environmental policy issues is the question, Can state and local governments effectively implement new strategies to address emerging environmental issues? This article examines two cases where state and local governments have taken and are taking a prominent role in addressing water quality problems. The cases, although different in time and focus, argue that state and local governments can, and have, provided leadership on such issues. Much of the early effort to push for national environmental mandates was based on the assumption that state and local governments were incapable of addressing the environmental challenges facing them. The two cases presented in this article suggest that more than national mandates are required to overcome local limits. Among the required components for successful state and local government efforts suggested by these cases are experimentation, innovative combinations of public and private organizations at the local and state levels, and flexible federal support for local action.