Presentation
Validation of a Collagen Fiber Recruitment Model for Uniaxial Loading of the Spinal Cord Injured Rat Urinary Bladder
Summer Biomechanics, Bioengineering, and Biotransport Conference
(2020)
Abstract
The knee menisci are fibrocartilaginous tissues that provide joint stability and protect articular cartilage by distributing joint loads. Overtime, mechanical wear due to age and overuse contributes to meniscus degeneration, a retrogressive pathological breakdown of meniscal fibrous tissue that affects 56% of the population above 70 years of age. Meniscus degeneration increases the risk of meniscus tears, cartilage loss, and osteoarthritis (OA). While it is known that meniscus degeneration has highly adverse effects, little is understood about the etiology of degenerative wear within human knees.
The study of mechanical wear requires experimental tools to quantify the removal of material from a surface by measuring mass or volume loss. For whole artificial joints, the standard method to measure in vitro mass loss of articulating parts is through gravimetrics. However, gravimetric analysis requires vacuum desiccation at various time points, and would not be suitable for hydrated soft tissue. Moreover, measurement of mass loss does not allow for the identification of regional wear patterns that occur in meniscus. Alternatively, micro-computerized tomography and magnetic resonance imaging can be used to quantify and map volumetric wear; however, these methods can be time consuming, costly, and have insufficient imaging resolution to preserve detail. A novel approach to measuring wear is through 3D optical scanning, which creates 3D reconstructions by emitting and recording light patterns on complex objects. While 3D optical scanning has the potential to provide a fast, low-cost, and accurate alternative for measuring in vitro wear in soft tissues, no study has developed a method to use this imaging technology to measure wear in meniscus, or any soft tissue. The objective of this research is to therefore develop and validate an in vitro methodology for characterizing volumetric wear behavior within meniscus utilizing a 3D optical scanning system.
Disciplines
Publication Date
June 18, 2020
Location
Virtual
Citation Information
Kate J. Benfield, Katherine A. Hollar and Trevor J. Lujan. "Validation of a Collagen Fiber Recruitment Model for Uniaxial Loading of the Spinal Cord Injured Rat Urinary Bladder" Summer Biomechanics, Bioengineering, and Biotransport Conference (2020) Available at: http://works.bepress.com/trevor_lujan/52/