Article
Short Sequences of Non-Proline Residues Can Adopt the Polyproline II Helical Conformation
Biochemistry
(2004)
Abstract
The left-handed polyproline II (PII) helix is a structure that has been given a great deal of attention lately because of its role in a wide variety of physiologically important processes and potential significance in protein unfolded states. Recent work by several authors has shown that residues besides proline can adopt this structure. A scale of relative PII-helix-forming propensities has been generated but only for single guest residues in a proline-based host system. Here, we present multiple guest residues in a proline-based host system. Using circular dichroism spectroscopy, we have shown that not only single residues, but also short sequences of non-proline residues can adopt the PII conformation.
Disciplines
Publication Date
2004
Citation Information
Brian W. Chellgren and Trevor P Creamer. "Short Sequences of Non-Proline Residues Can Adopt the Polyproline II Helical Conformation" Biochemistry Vol. 43 Iss. 19 (2004) Available at: http://works.bepress.com/trevor_creamer/8/