In a preceding article, pediatric nurses were introduced to the new Patient Protection and Affordable Care Act (PPAC; Public Law. No. 111-148). Essential to PPAC will be the transformation from the current inefficient and expensive health care system into a more evidence-based effective system of care. Integration of evidence can be complex and involve multiple systems for successful use of evidence. Strategically, nurses are on the forefront for being a part of the solution for transforming the health care delivery system. However, as previously discussed, nurses face many barriers to the implementation of evidence in their work. This current article will explore strategies for facilitating changes in organizational and individual nurse behaviors toward a context of promoting a more evidence-based system of effective, safe, and patient-centered health care.