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Article
Characterization of Cellular Uptake and Toxicity of Aminosilane-Coated Iron Oxide Nanoparticles with Different Charges in Central Nervous System-Relevant Cell Culture Models
International Journal of Nanomedicine (2013)
  • Zhizhi Sun
  • Vinith Yathindranath
  • Matthew Worden, Kent State University - Kent Campus
  • James A. Thliveris
  • Stephanie Chu
  • Fiona E. Parkinson
  • Torsten Hegmann, Kent State University - Kent Campus
  • Donald W. Miller
Abstract
Background: Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.
Keywords
  • Magnetic Nanoparticles,
  • Oxidative Stress,
  • Brain,
  • Cytotoxicity,
  • Aggregation,
  • Delivery,
  • Neurons
Disciplines
Publication Date
March 6, 2013
Publisher Statement

Originally published in International Journal of Nanomedicine by Dove Medical Press. Available on publisher's site at http://dx.doi.org/10.2147/IJN.S39048

Citation Information
Zhizhi Sun, Vinith Yathindranath, Matthew Worden, James A. Thliveris, et al.. "Characterization of Cellular Uptake and Toxicity of Aminosilane-Coated Iron Oxide Nanoparticles with Different Charges in Central Nervous System-Relevant Cell Culture Models" International Journal of Nanomedicine Vol. 8 (2013)
Available at: http://works.bepress.com/torsten_hegmann/4/