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Bayesian approach to guide termination of retrospective retesting after detection of a systematic quality control failure
Faculty of Health Sciences & Medicine Publications
  • Chin Hon Tan, University of Singapore
  • Guanghua Han, University of Singapore
  • Tze Ping Loh, University of Singapore Hospital
  • Tony Badrick, Bond University
Date of this Version
11-1-2014
Document Type
Journal Article
Publication Details

Citation only

Tan, C. Han, G., Loh, T. , & Badrick, T. (2014). Bayesian approach to guide termination of retrospective retesting after detection of a systematic quality control failure. Clinica Chimica Acta, 437, 52-57.

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© Copyright, Elsevier, 2014

Abstract

When a systematic error is detected in the analytical process, ideally, one seeks to retest only patient samples between the onset of the error and the time the error was detected. In practice, the onset of error is often unknown, and patient samples are retrospectively retested back to the last acceptable QC sample. This can be wasteful of reagents and operator time.

Methods: An alternative approach that is based on the expected number of spurious results is described to determine when retrospective retesting should terminate. Assuming each patient sample was independently measured by an analytical process with an underlying Gaussian distribution, a Bayesian model that takes into account the difference between the original and retest result of each patient sample was developed.

Results: We are able to significantly reduce the number of samples retested, while ensuring that the average number of spurious results observed under the proposed retesting procedure was similar to or only marginally higher than the baseline number of spurious results when the assay was in control.

Conclusion Patient samples measured after the systematic error have high probabilities of being retested under the proposed retesting procedure.

Citation Information
Chin Hon Tan, Guanghua Han, Tze Ping Loh and Tony Badrick. "Bayesian approach to guide termination of retrospective retesting after detection of a systematic quality control failure" (2014) ISSN: 0009-8981
Available at: http://works.bepress.com/tony_badrick/20/