Article
Associations between surgically-induced changes in knee loading and biochemical markers of knee inflammation
Osteoarthritis and Cartilage
(2021)
Abstract
Mechanically-induced inflammation is thought to contribute to osteoarthritis (OA) and may be a target for treatment. Substantial changes in knee load produced by high tibial osteotomy (HTO) provide a model to explore the relationship between changes in knee inflammation and load. Therefore, the objectives of this study were to 1) investigate changes in synovial fluid cytokines, chemokines, growth factors and matrix metalloproteases (MMPs), 1 year after HTO and 2) explore the associations of changes in these markers with changes in MRI measures of knee effusion-synovitis and surrogate measures of knee load during walking.
Disciplines
Publication Date
2021
Citation Information
Jenna Schulz, T Birmingham, K Leitch, J Giffin, et al.. "Associations between surgically-induced changes in knee loading and biochemical markers of knee inflammation" Osteoarthritis and Cartilage (2021) Available at: http://works.bepress.com/tom-appleton/4/