Background: Clinical practice guidelines (CPG) are helpful in improving patient care by translating current research into clinical recommendations to assist in clinical decision making. The purpose of this case report is to clinically apply the recommendations from the Academy of Orthopaedic Physical Therapy’s Ankle Stability and Movement Coordination Impairments: Lateral Ankle Sprains (LAS) Revision 2021 CPG.8 Case Description: A 34-year-old man was referred to physical therapy with a 16-year history of recurrent left ankle sprains and a diagnosis of chronic ankle instability (CAI). Chronic ankle stability is a condition characterized by ongoing ankle instability. The patient had decreased ankle dorsiflexion range of motion, lower quarter weakness, balance limitations, and pain. Outcome: In 6 sessions distributed over 8 weeks, the patient demonstrated clinically important improvements in ankle dorsiflexion, balance, lower quarter weakness without an appreciable change in ligamentous laxity and self-reported CAI. He returned to desired activities without recurrent sprains. Discussion: The rehabilitation program was informed by the LAS CPG. Interventions emphasized a home exercise program to address proprioceptive, strength, and mobility deficits. Clinical Relevance: This case report demonstrates the application of CPG recommendations used to inform patient-centered care.