Skip to main content
Contribution to Book
Modeling Brain Tumors using Avian Retroviral Gene Transfer
CNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches (2009)
  • Tod D Holland, San Jose State University
  • Eric C Holland
Abstract

RCAS/tv-a is a system for post-natal cell type specific gene transfer. It is used for the modeling of gliomas and medulloblastomas. This system provides a combination of lineage tracing from the cell origin with oncogenesis induced by mis-expression of specific genes. The genes that are most potent at inducing tumors are those that encode components of signal transduction and undifferentiated cells are most capable of serving as the cell of origin. The system effectively generates tumors with the histologic characteristics of human disease. Mice bearing RVAS/tv-a induced brain tumors are currently being used for preclinical trials to understand the biology of therapeutic response in the various cell types that make up gliomas and medulloblastomas

Publication Date
August, 2009
Editor
Erwin C. Van Meir
Publisher
Human Press
Citation Information
Tod D Holland and Eric C Holland. "Modeling Brain Tumors using Avian Retroviral Gene Transfer" Cold Spring Harbor, New YorkCNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches (2009)
Available at: http://works.bepress.com/tod_holland/1/