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Article
Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
  • Timothy Bigelow, Iowa State University
  • Clayton L. Thomas, Iowa State University
  • Huaiqing Wu, Iowa State University
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
10-18-2019
DOI
10.1109/TUFFC.2019.2948305
Abstract

There is a critical need to develop new noninvasive therapies to treat bacteria biofilms. Previous studies have demonstrated the effectiveness of cavitation-based ultrasound histotripsy to destroy these biofilms. In this study, the dependence of biofilm destruction on multiple scan parameters was assessed by conducting exposures at different scan speeds (0.3-1.4 beam widths/sec), step sizes (0.25-0.5 beam widths), and number of passes of the focus across the mesh (2-6). For each of the exposure conditions, the number of colony forming units (CFUs) remaining on the mesh was quantified. A regression analysis was then conducted revealing that scan speed was the most critical parameter for biofilm destruction. Reducing the number of passes and the scan speed should allow for more efficient biofilm destruction in the future reducing the treatment time.

Comments

This is a manuscript of an article published as Bigelow, T. A., C. L. Thomas, and H. Wu. "Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh." IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (2019). DOI: 10.1109/TUFFC.2019.2948305. Posted with permission.

Rights
© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Copyright Owner
IEEE
Language
en
File Format
application/pdf
Citation Information
Timothy Bigelow, Clayton L. Thomas and Huaiqing Wu. "Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh" IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (2019)
Available at: http://works.bepress.com/timothy_bigelow/30/