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Article
Dependence of ablative ability of high-intensity focused ultrasound cavitation-based histotripsy on mechanical properties of agar
Journal of the Acoustical Society of America
  • Jin Xu, Iowa State University
  • Timothy A. Bigelow, Iowa State University
  • Gabriel Davis, Iowa State University
  • Alex Avendano, Iowa State University
  • Pranav Shrotriya, Iowa State University
  • Kevin Bergler, Iowa State University
  • Zhong Hu, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
12-1-2014
DOI
10.1121/1.4898426
Abstract
Cavitation-based histotripsy uses high-intensity focused ultrasound at low duty factor to create bubble clouds inside tissue to liquefy a region, and provides better fidelity to planned lesion coordinates and the ability to perform real-time monitoring. The goal of this study was to identify the most important mechanical properties for predicting lesion dimensions, among these three: Young's modulus, bending strength, and fracture toughness. Lesions were generated inside tissue-mimicking agar, and correlations were examined between the mechanical properties and the lesion dimensions, quantified by lesion volume and by the width and length of the equivalent bubble cluster. Histotripsy was applied to agar samples with varied properties. A cuboid of 4.5mm width (lateral to focal plane) and 6mm depth (along beam axis) was scanned in a raster pattern with respective step sizes of 0.75 and 3mm. The exposure at each treatment location was either 15, 30, or 60s. Results showed that only Young's modulus influenced histotripsy's ablative ability and was significantly correlated with lesion volume and bubble cluster dimensions. The other two properties had negligible effects on lesion formation. Also, exposure time differentially affected the width and depth of the bubble cluster volume.
Comments

The following article appeared in Journal of the Acoustical Society of America 136 (2014): 3018 and may be found at doi: 10.1121/1.4898426.

Rights
Copyright 2014 Acoustical Society of America. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the Acoustical Society of America.
Copyright Owner
Acoustical Society of America
Language
en
File Format
application/pdf
Citation Information
Jin Xu, Timothy A. Bigelow, Gabriel Davis, Alex Avendano, et al.. "Dependence of ablative ability of high-intensity focused ultrasound cavitation-based histotripsy on mechanical properties of agar" Journal of the Acoustical Society of America Vol. 136 Iss. 6 (2014) p. 3018 - 3027
Available at: http://works.bepress.com/timothy_bigelow/19/