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Dependence of Cavitation Bubble Size on Pressure Amplitude at Therapeutic Levels
AIP Conference Proceedings
  • Kelsey Jean Carvell, Iowa State University
  • Timothy A. Bigelow, Iowa State University
Document Type
Conference Proceeding
Publication Date
High‐intensity, focused ultrasound therapy is a minimally invasive therapy technique that is effective and relatively safe. It can be used in areas including histotripsy, thermal ablation, and administering medication. Inertial cavitation is used to improve these therapy methods. The purpose of this study was to determine the effect of pressure amplitude on cavitation resonance frequency/bubble size at therapeutic field levels. Earlier work has indicated that the resonance size depends on pressure amplitude; however, the investigation only considered pressure amplitudes up to 1 MPa [1]. Our study was conducted by simulating the response of bubbles to linearly propagating sine waves using the Gilmore‐Akulichev formulation to solve for the bubble response. The frequency of the sine wave varied from 1 to 5 MHz while the amplitude of the sine wave varied from 0.0001 to 9 MPa. The resonance size for a particular frequency of excitation and amplitude was determined by finding the initial bubble size that resulted in the maximum bubble expansion for an air bubble in water. The simulations demonstrated a downshift in resonance size with increasing pressure amplitude. Therefore, smaller bubbles will have a more dramatic response to ultrasound at therapeutic levels.

The following article appeared in AIP Conference Proceedings 1113 (2009): 63 and may be found at doi:10.1063/1.3131472.

Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.
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American Institute of Physics
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Citation Information
Kelsey Jean Carvell and Timothy A. Bigelow. "Dependence of Cavitation Bubble Size on Pressure Amplitude at Therapeutic Levels" AIP Conference Proceedings Vol. 1113 (2009) p. 63 - 67
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