Article
Quantitation of Nanoparticles in Serum Matrix by Capillary Electrophoresis
Methods in Molecular Biology: Characterization of Nanoparticles Intended for Drug Delivery
Document Type
Article
Publication Date
1-1-2011
DOI
10.1007/978-1-60327-198-1_15
PubMed ID
21116963
Abstract
Sensitive and fast analytical techniques are needed to determine the concentration of nanoparticles in biological samples (e.g., blood and tissues) for biodistribution and toxicity studies. This chapter describes a method for the use of capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) for the quantitation of fullerene nanoparticles in human serum matrix. Data on the fullerene-based nanoparticle carboxyfullerene (C3 fullerene) in human serum is presented as an example.
Disciplines
Keywords
- Calibration,
- chromatography,
- electrophoresis,
- capillary,
- nanoparticles,
- serum,
- tissue distribution
Citation Information
King C. Chan, Timothy D. Veenstra and Haleem J. Issaq. "Quantitation of Nanoparticles in Serum Matrix by Capillary Electrophoresis" Methods in Molecular Biology: Characterization of Nanoparticles Intended for Drug Delivery Vol. 697 (2011) p. 145 - 153 ISSN: 1940-6029 Available at: http://works.bepress.com/timothy-veenstra/74/