Article
High-resolution serum proteomic features for ovarian cancer detection.
Endocrine-Related Cancer
Document Type
Article
Publication Date
6-1-2004
DOI
10.1677/erc.0.0110163
PubMed ID
15163296
Abstract
Serum proteomic pattern diagnostics is an emerging paradigm employing low-resolution mass spectrometry (MS) to generate a set of biomarker classifiers. In the present study, we utilized a well-controlled ovarian cancer serum study set to compare the sensitivity and specificity of serum proteomic diagnostic patterns acquired using a high-resolution versus a low-resolution MS platform. In blinded testing sets, the high-resolution mass spectral data contained multiple diagnostic signatures that were superior to the low-resolution spectra in terms of sensitivity and specificity (P
Disciplines
Keywords
- Biomarkers,
- tumor,
- blood proteins,
- diagnosis,
- differential,
- neoplasm proteins,
- ovarian neoplasms,
- proteomics,
- spectrometry,
- mass
Citation Information
T. P. Conrads, V. A. Fusaro, S. Ross, D. Johann, et al.. "High-resolution serum proteomic features for ovarian cancer detection." Endocrine-Related Cancer Vol. 11 Iss. 2 (2004) p. 163 - 178 ISSN: 1351-0088 Available at: http://works.bepress.com/timothy-veenstra/290/