Article
Targeted Proteomics for Validation of Biomarkers in Clinical Samples
Briefings in Functional Genomics & Proteomics
Document Type
Article
Publication Date
3-1-2009
DOI
10.1093/bfgp/eln050
PubMed ID
19109305
PubMed Central® ID
PMC2722261
Abstract
The rapid rise and application of proteomic technologies has resulted in an exponential increase in the number of proteins that have been discovered and presented as 'potential' biomarkers for specific diseases. Unfortunately, the number of biomarkers approved for use by the Food and Drug Administration has not risen in likewise manner. While there are a number of reasons for this discrepancy, this glut of 'potential' biomarkers also indicates the need for validation methods to confirm or refute their utility in clinical diagnostics. For this reason, the emphasis on developing methods to target and measure the absolute quantity of specific proteins and peptides in complex proteomic samples has grown.
Disciplines
Keywords
- Biomarkers,
- computational biology,
- gene expression profiling,
- genomics,
- ions,
- mass spectrometry,
- peptides,
- proteins,
- proteome,
- proteomics,
- receptor,
- ErbB-2,
- reproducibility of results
Citation Information
Xiaoying Ye, Josip Blonder and Timothy D. Veenstra. "Targeted Proteomics for Validation of Biomarkers in Clinical Samples" Briefings in Functional Genomics & Proteomics Vol. 8 Iss. 2 (2009) p. 126 - 135 ISSN: 1477-4062 Available at: http://works.bepress.com/timothy-veenstra/144/