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Improving pregnancy outcomes in humans through studies in sheep
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
  • Janna L. Morrison, University of South Australia
  • Mary J. Berry, University of Otago
  • Kimberley J. Botting, University of Cambridge
  • Jack R.T. Darby, University of South Australia
  • Martin G. Frasch, University of Washington
  • Kathryn L. Gatford, Adelaide Medical School
  • Dino A. Giussani, University of Cambridge
  • Clint L. Gray, University of Otago
  • Richard Harding, Monash University
  • Emilio A. Herrera, Facultad de Medicina de la Universidad de Chile
  • Matthew W. Kemp, The University of Western Australia
  • Mitchell C. Lock, University of South Australia
  • I. Caroline McMillen, University of South Australia
  • Timothy J. Moss, Monash University
  • Gabrielle C. Musk, The University of Western Australia
  • Mark H. Oliver, Liggins Institute
  • Timothy R.H. Regnault, Children's Health Research Institute, London, ON
  • Claire T. Roberts, Adelaide Medical School
  • Jia Yin Soo, University of South Australia
  • Ross L. Tellam, University of South Australia
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Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.

Citation Information
Janna L. Morrison, Mary J. Berry, Kimberley J. Botting, Jack R.T. Darby, et al.. "Improving pregnancy outcomes in humans through studies in sheep" American Journal of Physiology - Regulatory Integrative and Comparative Physiology Vol. 315 Iss. 6 (2018) p. R1123 - R1153
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