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Selected Works of Timothy Crawford
Article
A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients
Family Medicine Faculty Publications
  • Inski H. Yu
  • Alive C. Thornton
  • Timothy N. Crawford, Wright State University
  • Thein Myint
Link
Document Type
Poster
Publication Date
1-1-2015
Disciplines
Abstract

• There are several causes of macrocytosis, such as vitamin B12 or folic acid deficiency, alcoholism, drug-induced conditions such as hydroxyurea, and certain HIV medications such as zidovudine (AZT).

• The mean corpuscular volume (MCV) increased by a mean 3% at week 4, and 14% at 12 weeks after starting AZT. Macrocytosis (MCV >100 fl, normal 79 – 98fL) was present in 78% - 88% in HIV-infected patients treated with AZT.

• There is limited literature on duration of persistence of macrocytosis after AZT is discontinued.

• This study aims to characterize the duration and causes of persistent macrocytosis after discontinuation of AZT.

Citation Information
Inski H. Yu, Alive C. Thornton, Timothy N. Crawford and Thein Myint. "A Study on Persistence of Macrocytosis after Discontinuation of Zidovudine in HIV-Infected Cohort Patients" (2015)
Available at: http://works.bepress.com/timothy-crawford/49/