Skip to main content
Article
A Prospective Analysis of Factors Associated with Decreased Physical Activity in Patients with Cirrhosis Undergoing Transplant Evaluation
Clinical Transplantation
  • Anna Christina Dela Cruz, University of Kentucky
  • Valery Vilchez, University of Kentucky
  • Sooyeon Kim, University of Kentucky
  • Benjamin Barnes, University of Kentucky
  • Abhishek Ravinuthala, University of Kentucky
  • Anthony Zanni, University of Kentucky
  • Roberto Galuppo, University of Kentucky
  • Achuthan Sourianarayanane, University of Kentucky
  • Trushar Patel, University of Kentucky
  • Erin Colleen Maynard, University of Kentucky
  • Malay B. Shah, University of Kentucky
  • Michael F. Daily, University of Kentucky
  • Timothy L. Uhl, University of Kentucky
  • Karyn A. Esser, University of Kentucky
  • Roberto Gedaly, University of Kentucky
Abstract
BACKGROUND: Physical activity has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. AIM: To evaluate predictors of physical activity and grip strength in cirrhotic patients undergoing liver transplant evaluation. METHODS: Single center, prospective analysis. RESULTS: A hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic hepatitis (27%), hepatitis C (22%), and alcoholic liver disease (21%). Mean MELD score was 13.5. Forty one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire. The median total physical activity score of 33 MET-min/weeks. The mean total grip strength was 62.1 ± 22lb. Total grip strength was found to be an independent predictor of low-moderate physical activity (OR 4.7, 95% CI 1.4-16.2, p=0.038) and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p=0.005). CONCLUSIONS: End-Stage Liver Disease patients undergoing liver transplant evaluation have reduced total physical activity by IPAQ. Total Grip Strength was found to be a significant predictor of low-moderate physical activity in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics. This article is protected by copyright. All rights reserved.
Document Type
Article
Publication Date
11-1-2015
Notes/Citation Information

Published in Clinical Transplantation, v. 29, issue 11, p. 958-964.

© 2015 John Wiley & Sons A/S.

This is the peer reviewed version of the following article: Dela Cruz AC, Vilchez V, Kim S, Barnes B, Ravinuthala A, Zanni A, Galuppo R, Sourianarayanane A, Patel T, Maynard E, Shah MB, Daily MF, Uhl T, Esser K, Gedaly R. (2015). A Prospective Analysis of Factors Associated with Decreased Physical Activity in Patients with Cirrhosis Undergoing Transplant Evaluation. Clinical Transplantation, 29:11, 958-964, which has been published in final form at https://doi.org/10.1111/ctr.12602. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Digital Object Identifier (DOI)
https://doi.org/10.1111/ctr.12602
Funding Information

Funded by the Center for Muscle Biology at the University of Kentucky.

Citation Information
Anna Christina Dela Cruz, Valery Vilchez, Sooyeon Kim, Benjamin Barnes, et al.. "A Prospective Analysis of Factors Associated with Decreased Physical Activity in Patients with Cirrhosis Undergoing Transplant Evaluation" Clinical Transplantation Vol. 29 Iss. 11 (2015) p. 958 - 964
Available at: http://works.bepress.com/tim_uhl/118/