The Santa Clara Strength of Religious Faith Questionnaire (SCSORF) is an often used and validated scale that is uncommonly utilized in culturally diverse populations. The purpose of this research investigation was to adapt the SCSORF for use among Iranian Muslim patients undergoing dialysis and to examine the reliability and validity of the scale among this population. A total of 428 patients (228 females, 200 males, M age = 52.2 years, SD = 10) were selected from five dialysis center in Tehran and Qazvin, Iran. A comprehensive forward–backward translation system was used for cross-cultural translation. Patients completed a baseline questionnaire obtaining demographic and clinical information as well as the SCSORF, the Age Universal Religious Orientation Scale (AUROS), the religious life inventory (RLI), and the Duke University religion index (DUREL). 2 weeks later, patients were asked to complete the SCSORF once again. Reliability of the SCSORF was examined using internal consistency and test-rest reliability. Convergent validity and factor structure using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were also examined. Cronbach’s α for the single construct of the SCSORF was 0.89 with adequate test–retest reliability measured over a 2 week period. SCSORF scores were significantly correlated with AUROS, RLI and the DUREL. The EFA generated a single factor solution for the SCSORF while these results were confirmed by the CFA in an independent sample. Findings demonstrated that the SCSORF has favorable reliability, convergent validity, and divergent validity among Iranian Muslim patients undergoing dialysis and is recommended for use by clinicians (e.g., nephrologists) to measure strength of religious faith among patients.