The Jesuit Examen is a form of prayerful reflection on daily experiences that was introduced five centuries ago by St. Ignatius of Loyola, founder of the Society of Jesus (better known as the Jesuits). The Examen may be utilized by diverse populations when adapted and secularized, which can be completed by substituting the language of God in the original Examen for more inclusive terms such as “love.” Although five centuries old, the 10–15-min daily reflective practice has not been subject to empirical research. Furthermore, research has not explored the effects of the Examen on psychological health and well-being in a workplace setting. Other religious practices, including mindfulness and yoga, are important and religiously derived but now secularized interventions that can be utilized in multiple work and other settings. The present pilot study focused on the potential effectiveness of using a secularized version of the Examen in the workplace to determine whether this practice can produce psychological and well-being health benefits, such as stress reduction and improvement in one’s satisfaction with life.