The Examen is a 500-year-old end of day prayer developed by St. Ignatius of Loyola, founder of the Society of Jesus (better known as the Jesuits). Like many other religious or spiritual practices, such as mindfulness and yoga, the Examen is suitable as either a spiritually focused or secular intervention strategy to assist people within clinical psychotherapy practice and elsewhere. Adapting the Examen as a cognitive behavioral psychotherapy intervention is easy to do and may add another important tool to the toolbox of practicing clinicians interested in thoughtfully integrating spiritually based approaches in their clinical work with religiously as well as nonreligiously minded clients.