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Article
mitoNEET as a Novel Drug Target for Mitochondrial Dysfunction
Drug Discovery Today
  • Werner J Geldenhuys
  • Thomas C Leeper, University of Akron Main Campus
  • Richard T Carroll
Document Type
Article
Publication Date
10-1-2014
Disciplines
Abstract
Mitochondrial dysfunction plays an important part in the pathology of several diseases, including Alzheimer's disease and Parkinson's disease. Targeting mitochondrial proteins shows promise in treating and attenuating the neurodegeneration seen in these diseases, especially considering their complex and pleiotropic origins. Recently, the mitochondrial protein mitoNEET [also referred to as CDGSH iron sulfur domain 1 (CISD1)] has emerged as the mitochondrial target of thiazolidinedione drugs such as the antidiabetic pioglitazone. In this review, we evaluate the current understanding regarding how mitoNEET regulates cellular bioenergetics as well as the structural requirements for drug compound association with mitoNEET. With a clear understanding of mitoNEET function, it might be possible to develop therapeutic agents useful in several different diseases including neurodegeneration, breast cancer, diabetes and inflammation.
Citation Information
Werner J Geldenhuys, Thomas C Leeper and Richard T Carroll. "mitoNEET as a Novel Drug Target for Mitochondrial Dysfunction" Drug Discovery Today Vol. 19 Iss. 10 (2014) p. 1601 - 1606
Available at: http://works.bepress.com/thomas_leeper/2/