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Article
The Effect of Enzyme Replacement Therapy with Imiglucerase on Bone Mineral Density in Type 1 Gaucher Disease
Journal of Bone and Mineral Research
  • Richard J. Wenstrup
  • Katherine A. Kacena
  • Paige Kaplan
  • Gregory M. Pastores
  • Ainu Prakash-Cheng
  • Ari Zimran
  • Thomas N. Hangartner, Wright State University - Main Campus
Document Type
Article
Publication Date
1-1-2007
Abstract
The effect of ERT with imiglucerase on BMD in type 1 GD was studied using BMD data from the International Collaborative Gaucher Group Gaucher Registry. Data were analyzed for 160 untreated patients and 342 ERT-treated patients. Imiglucerase significantly improves BMD in patients with GD, with 8 years of ERT leading to normal BMD. Introduction: The objective was to determine the effect of enzyme replacement therapy (ERT; Cerezyme, imiglucerase) on BMD in type 1 Gaucher disease (GD). Materials and Methods: The study population included all adults (men, 18–70 years; women, 18–50 years) enrolled in the International Collaborative Gaucher Group (ICGG) Gaucher Registry for whom lumbar spine BMD measurements were available. BMD data with up to 8 years of follow-up were analyzed for 160 patients who received no ERT and 342 patients treated with ERT alone. BMD was assessed by DXA of the lumbar spine. Z scores for patients with GD were compared with a reference population. From the model's estimate, percent of patients by age and sex with osteoporosis (T score ⩽ −2.5) were calculated. Results: DXA Z scores for patients with GD in the no ERT (untreated) group were significantly below normal (y intercept = −0.80 Z score units, p < 0.001) and remained ˜1 SD below the reference population over time (slope = −0.010 Z score units per year, p = 0.68). The DXA Z scores for patients with GD who received ERT at a dose of 60 U/kg/2 weeks were significantly lower than the reference population at baseline (y-intercept = −1.17 Z score units, p < 0.001), but improved significantly over time (slope = +0.132 Z score units per year, p < 0.001). A significant dose–response relationship was noted for the ERT group, with the slopes for the three main dosing groups of 15, 30, and 60 U/kg/2 weeks of +0.064, +0.086, and +0.132 Z score units per year, respectively. The BMD of patients with GD treated with ERT increased to −0.12 (60 U/kg/2 weeks), −0.48 (30 U/kg/2 weeks), and −0.66 (15 U/kg/2 weeks) SD of the mean of the reference population after 8 years of ERT, approaching the reference population. Estimated risk of osteoporosis of this GD population, if left untreated, ranged from ˜10 to 30% in women and 10% to 25% in men. Conclusions: ERT with imiglucerase (Cerezyme) may increase BMD in patients with GD. Response to treatment with imiglucerase is slower for BMD than for hematologic and visceral aspects of GD. A normal (age- and sex-adjusted) BMD should be a therapeutic goal for patients with type 1 GD.
DOI
10.1359/jbmr.061004
Citation Information
Richard J. Wenstrup, Katherine A. Kacena, Paige Kaplan, Gregory M. Pastores, et al.. "The Effect of Enzyme Replacement Therapy with Imiglucerase on Bone Mineral Density in Type 1 Gaucher Disease" Journal of Bone and Mineral Research Vol. 22 Iss. 1 (2007) p. 119 - 126 ISSN: 0884-0431
Available at: http://works.bepress.com/thomas_hangartner/94/