A Study of the Long-Term Precision of Dual-Energy X-Ray Absorptiometry Bone Densitometers and Implications for the Validity of the Least-Significant-Change CalculationOsteoporosis International
AbstractIntroduction Short-term precision is often quoted and used as the most important performance parameter of a dual-energy X-ray absorptiometry (DXA) scanner; however, long-term precision has a more profound impact on patient monitoring. Long-term precision refers to the combination of in-vivo precision errors and long-term equipment stability. Methods To monitor long-term equipment stability, a phantom was designed with four inserts ranging in bone-mineral density from 0.5 to 3.3 g/cm2. This phantom was used to monitor the equipment stability of four modern fan-beam densitometers, two each from Hologic and GE/Lunar, over a 4-year period. Manufacturer-recommended quality assurance (QA) procedures were performed, and the scanners stayed within manufacturer-specified tolerances throughout the study. Results and conclusion During the 4-year period, the Hologic scanners were observed to cause clinically insignificant BMD shifts (maximum of 0.34%), whereas the GE/Lunar scanners revealed BMD shifts that were clinically significant (1.5% and 2.1%). As a result, using least-significant-change (LSC) calculations based only on short-term in-vivo precision studies for monitoring patients is not valid for the two GE/Lunar densitometers due to the poorer long-term stability they exhibited.
Citation InformationThomas N. Hangartner. "A Study of the Long-Term Precision of Dual-Energy X-Ray Absorptiometry Bone Densitometers and Implications for the Validity of the Least-Significant-Change Calculation" Osteoporosis International Vol. 18 Iss. 4 (2007) p. 513 - 523 ISSN: 0937-941X
Available at: http://works.bepress.com/thomas_hangartner/62/