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Article
The plasma renin-angiotensin system in preeclampsia: effects of magnesium sulfate.
Obstetrics and gynecology
  • S. L. Sipes
  • C. P. Weiner
  • Thomas M. Gellhaus, University of Iowa
  • J. D. Goodspeed
Document Type
Article
Peer Reviewed
1
Publication Date
6-1-1989
Abstract
Two groups of women were studied in a prospective longitudinal fashion to determine the effects of a 2.5-hour infusion of magnesium sulfate upon the renin-angiotensin system. Serum magnesium concentration, angiotensin-converting enzyme concentration, and plasma renin activity were measured at uniform intervals in women with either preeclampsia or preterm labor. Plasma renin activity was significantly lower (3.9 +/- 2.2 versus 6.1 +/- 1.8 ng/mL/minute; P = .004) and angiotensin-converting enzyme significantly higher (47.1 +/- 14 versus 34.0 +/- 10 U/mL; P = .008) in women with preeclampsia than in those with preterm labor. Magnesium infusion was associated with a sustained decline in plasma renin activity in preeclamptic women (P = .003). A transient decline in angiotensin-converting enzyme (P = .009) was observed in women with preeclampsia, but not with preterm labor. In contrast to the sustained change in plasma renin activity, angiotensin-converting enzyme concentration returned to baseline activity levels by 2.5 hours. A nonsignificant negative relationship (P = .06) was noted between angiotensin-converting enzyme and gestational age in subjects with preeclampsia. We conclude that a short-term infusion of magnesium sulfate leads to a sustained decline in plasma renin activity in preeclamptic women, but exerts no sustained effect on angiotensin-converting enzyme in women with either preeclampsia or preterm labor.
Keywords
  • Adult,
  • Depression,
  • Chemical,
  • Female,
  • Humans,
  • Longitudinal Studies,
  • Magnesium Sulfate,
  • Obstetric Labor,
  • Premature,
  • Peptidyl-Dipeptidase A,
  • Pre-Eclampsia,
  • Pregnancy,
  • Prospective Studies,
  • Renin,
  • Renin-Angiotensin System,
  • Time Factors
Published Article/Book Citation
Obstetrics and gynecology (1989) 73:6, pp. 934-937.
Citation Information
S. L. Sipes, C. P. Weiner, Thomas M. Gellhaus and J. D. Goodspeed. "The plasma renin-angiotensin system in preeclampsia: effects of magnesium sulfate." Obstetrics and gynecology Vol. 73 Iss. 6 (1989) p. 934 - 937 ISSN: 0029-7844
Available at: http://works.bepress.com/thomas_gellhaus/5/