The effect of intramuscular (i.m.) omeprazole (0.25 or 1.0 mg/kg bwt; LD and HD), respectively, on volume, total acid output (TAO) and pH of the gastric juice was studied during 24 h in 5 horses with a chronically implanted gastric cannula. Whether secretion in controls was basal or stimulated with pentagastrin (8 μg/kg bwt/h), volume (NS) and TAO (P<0.01, NS) gradually decreased and pH increased (P<0.05, NS).
Omeprazole significantly reduced the average basal TAO by 49 ± 6% (LD) and 88 ± 3% (HD) and the stimulated TAO by 64 ± 2% and 97 ± 1%. Basal pH in controls was 2.1–4.2 and after omeprazole treatment, pH 2.8–4.1 (LD) and 2.4–6.6 (HD). After stimulation, the corresponding pH values were 2.6–3.3, 3.9–4.9 and 5.4–7.2. The biological availability of omeprazole was 70–80%. Due to the simplicity of the administration technique and the higher biological availability, intramuscular administration may offer a practical and less expensive way of treating gastric ulcers in horses.
- horse; intramuscular omeprazole; acid inhibition
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