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Article
Metoclopramide Ameliorates the Effects of Endotoxin on Gastric Emptying of Acetaminophen in Horses
Canadian Journal of Veterinary Research (1999)
  • Thomas J Doherty, University of Tennessee, Knoxville
  • F. M. Andrews, University of Tennessee, Knoxville
  • T. W. Abraha, University of Tennessee, Knoxville
  • D. Osborne, University of Tennessee, Knoxville
  • D. L. Frazier, University of Tennessee, Knoxville
Abstract

The effect of metoclopramide on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses (n = 7), horses given endotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs time curve (AUC) were compared among treatment groups. Endotoxin caused a profound delay in gastric emptying, and pretreatment with metoclopramide significantly (P < 0.05) ameliorated this effect.

Publication Date
January, 1999
Citation Information
Thomas J Doherty, F. M. Andrews, T. W. Abraha, D. Osborne, et al.. "Metoclopramide Ameliorates the Effects of Endotoxin on Gastric Emptying of Acetaminophen in Horses" Canadian Journal of Veterinary Research Vol. 63 Iss. 1 (1999)
Available at: http://works.bepress.com/thomas_doherty/20/