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Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize
Genes & Development
  • Jianbo Zhang, Iowa State University
  • Chuanhe Yu, Iowa State University
  • Vinay Pulletikurti, Illinois State University
  • Jonathan Lamb, University of Missouri
  • Tatiana Danilova, University of Missouri
  • Daniel F. Weber, Illinois State University
  • James Birchler, University of Missouri
  • Thomas Peterson, Iowa State University
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Publication Version
Published Version
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Barbara McClintock reported that the Ac/Ds transposable element system can generate major chromosomal rearrangements (MCRs), but the underlying mechanism has not been determined. Here, we identified a series of chromosome rearrangements derived from maize lines containing pairs of closely linked Ac transposable element termini. Molecular and cytogenetic analyses showed that the MCRs in these lines comprised 17 reciprocal translocations and two large inversions. The breakpoints of all 19 MCRs are delineated by Ac termini and characteristic 8-base-pair target site duplications, indicating that the MCRs were generated by precise transposition reactions involving the Ac termini of two closely linked elements. This alternative transposition mechanism may have contributed to chromosome evolution and may also occur during V(D)J recombination resulting in oncogenic translocations.

This article is from Genes & Development 23 (2009): 755, doi: 10.1101/gad.1776909. Posted with permission.

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Cold Spring Harbor Laboratory Press
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Citation Information
Jianbo Zhang, Chuanhe Yu, Vinay Pulletikurti, Jonathan Lamb, et al.. "Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize" Genes & Development Vol. 23 (2009) p. 755 - 765
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