Skip to main content
Article
Synchronization of Developmental Processes and Defense Signaling by Growth Regulating Transcription Factors
PloS ONE
  • Jinyi Liu, University of Tennessee, Knoxville
  • J. Hollis Rice, University of Tennessee, Knoxville
  • Nana Chen, University of Tennessee, Knoxville
  • Thomas J. Baum, Iowa State University
  • Tarek Hewezi, University of Tennessee, Knoxville
Document Type
Article
Publication Version
Published Version
Publication Date
5-29-2014
DOI
10.1371/journal.pone.0098477
Abstract
Growth regulating factors (GRFs) are a conserved class of transcription factor in seed plants. GRFs are involved in various aspects of tissue differentiation and organ development. The implication of GRFs in biotic stress response has also been recently reported, suggesting a role of these transcription factors in coordinating the interaction between developmental processes and defense dynamics. However, the molecular mechanisms by which GRFs mediate the overlaps between defense signaling and developmental pathways are elusive. Here, we report large scale identification of putative target candidates of Arabidopsis GRF1 and GRF3 by comparing mRNA profiles of the grf1/grf2/grf3 triple mutant and those of the transgenic plants overexpressing miR396-resistant version of GRF1 or GRF3. We identified 1,098 and 600 genes as putative targets of GRF1 and GRF3, respectively. Functional classification of the potential target candidates revealed that GRF1 and GRF3 contribute to the regulation of various biological processes associated with defense response and disease resistance. GRF1 and GRF3 participate specifically in the regulation of defense-related transcription factors, cell-wall modifications, cytokinin biosynthesis and signaling, and secondary metabolites accumulation. GRF1 and GRF3 seem to fine-tune the crosstalk between miRNA signaling networks by regulating the expression of several miRNA target genes. In addition, our data suggest that GRF1 and GRF3 may function as negative regulators of gene expression through their association with other transcription factors. Collectively, our data provide new insights into how GRF1 and GRF3 might coordinate the interactions between defense signaling and plant growth and developmental pathways.
Comments

This article is published as Liu J, Rice JH, Chen N, Baum TJ, Hewezi T (2014) Synchronization of Developmental Processes and Defense Signaling by Growth Regulating Transcription Factors. PLoS ONE 9(5): e98477. doi:10.1371/journal.pone.0098477. Posted with permission.

Creative Commons License
Creative Commons Attribution 4.0
Copyright Owner
Liu et al.
Language
en
File Format
application/pdf
Citation Information
Jinyi Liu, J. Hollis Rice, Nana Chen, Thomas J. Baum, et al.. "Synchronization of Developmental Processes and Defense Signaling by Growth Regulating Transcription Factors" PloS ONE Vol. 9 Iss. 5 (2014) p. e98477
Available at: http://works.bepress.com/thomas-baum/31/