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Article
Members of the Meloidogyne Avirulence Protein Family Contain Multiple Plant Ligand-Like Motifs
Phytopathology
  • William B. Rutter, Iowa State University
  • Tarek Hewezi, University of Tennessee, Knoxville
  • Tom R. Maier, Iowa State University
  • Melissa G. Mitchum, University of Missouri
  • Eric L. Davis, North Carolina State University
  • Richard S. Hussey, University of Georgia
  • Thomas J. Baum, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
8-1-2014
DOI
10.1094/PHYTO-11-13-0326-R
Abstract
Sedentary plant-parasitic nematodes engage in complex interactions with their host plants by secreting effector proteins. Some effectors of both root-knot nematodes (Meloidogynespp.) and cyst nematodes (Heterodera and Globodera spp.) mimic plant ligand proteins. Most prominently, cyst nematodes secrete effectors that mimic plant CLAVATA3/ESR-related (CLE) ligand proteins. However, only cyst nematodes have been shown to secrete such effectors and to utilize CLE ligand mimicry in their interactions with host plants. Here, we document the presence of ligand-like motifs in bona fide root-knot nematode effectors that are most similar to CLE peptides from plants and cyst nematodes. We have identified multiple tandem CLE-like motifs conserved within the previously identified Meloidogyneavirulence protein (MAP) family that are secreted from root-knot nematodes and have been shown to function in planta. By searching all 12 MAP family members from multiple Meloidogyne spp., we identified 43 repetitive CLE-like motifs composing 14 unique variants. At least one CLE-like motif was conserved in each MAP family member. Furthermore, we documented the presence of other conserved sequences that resemble the variable domains described in Heterodera and Globodera CLE effectors. These findings document that root-knot nematodes appear to use CLE ligand mimicry and point toward a common host node targeted by two evolutionarily diverse groups of nematodes. As a consequence, it is likely that CLE signaling pathways are important in other phytonematode pathosystems as well.
Comments

This article is published as Rutter, W. B., Hewezi, T., Maier, T. R., Mitchum, M. G., Davis, E. L., Hussey, R. S., and Baum, T. J. 2014. Members of the Meloidogyne avirulence protein family contain multiple plant ligand-like motifs. Phytopathology 104:879-885, doi: 10.1094/PHYTO-11-13-0326-R. Posted with permission.

Copyright Owner
The American Phytopathological Society
Language
en
File Format
application/pdf
Citation Information
William B. Rutter, Tarek Hewezi, Tom R. Maier, Melissa G. Mitchum, et al.. "Members of the Meloidogyne Avirulence Protein Family Contain Multiple Plant Ligand-Like Motifs" Phytopathology Vol. 104 Iss. 8 (2014) p. 879 - 885
Available at: http://works.bepress.com/thomas-baum/23/